Study of pyridoxylated hemoglobin as oxygen carrying blood substitute. Preparation, separation and preservation.

The Evaluation of the Efficacy of Oxygent® as an Oxygen-Carrying Substitute on Cerebral Blood Flow

Cerebral blood flow (CBF) is tightly regulated to meet metabolic demands, and it increases during hemodilution as arterial oxygen content (CaO2) falls. Oxygent® is a perfluorocarbon (PFC) emulsion that has a high capacity to dissolve oxygen and can thus increase CaO2 in patients breathing supplemental oxygen. PFCs have shown excellent oxygen therapeutic value in both phase II and phase III clin...

Soluble dextran-hemoglobin complex as a potential blood substitute.

A complex between soluble dextran and human hemoglobin has been synthesized by two different methods. In the alkylation method, hemoglobin was allowed to react with bromoacetyl groups incorporated into the dextran; the yield of the complex was about 80% in terms of the hemoglobin used. In the dialdehyde method, hemoglobin was allowed to react with dialdehyde groups on the dextran generated by p...

Hemoglobin-based oxygen-carrying resuscitation fluids.

Blood Gases and Cooximetry in Retired Racing Greyhounds: Unique Hemoglobin Physiology and Oxygen Carrying Properties Thesis

....................................................................................................................... ii DEDICATION ................................................................................................................... iv ACKNOWLEDGMENTS .................................................................................................. v VITA .........................

Coboglobins: oxygen-carrying cobalt-reconstituted hemoglobin and myoglobin.

In this work we show that it is possible to prepare and study a cobalt-substituted hemoglobin-a coboglobin (Cb).-and that this reconstituted metalloprotein exhibits reversible oxygen binding. The effect of the protein environment on Co(II)-protoporphyrin IX is directly observed by esr measurements on deoxy- and oxy-Cb and by oxygen uptake measurements, all of which may be compared with similar ...